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Predicted functional pathways based on KEGG annotations associated with H. pylori infection and eradication status. (A) Relative representation of predicted pathways between H. pylori –negative and H. pylori –positive samples **, P < 0.01; ***, P < 0.001 for two-group comparison. (B) Relative changes in predicted functional pathways between baseline and follow-up samples across eradicated, recurrent GC after eradication, and non-eradicated groups. Functional profiles were predicted from <t>16S</t> <t>rRNA</t> gene sequencing data using KEGG-based pathway inference. *, P < 0.05; ***, P < 0.001 for comparison between baseline and follow-up in each group. KEGG, Kyoto Encyclopedia of Genes and Genomes.
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Predicted functional pathways based on KEGG annotations associated with H. pylori infection and eradication status. (A) Relative representation of predicted pathways between H. pylori –negative and H. pylori –positive samples **, P < 0.01; ***, P < 0.001 for two-group comparison. (B) Relative changes in predicted functional pathways between baseline and follow-up samples across eradicated, recurrent GC after eradication, and non-eradicated groups. Functional profiles were predicted from 16S rRNA gene sequencing data using KEGG-based pathway inference. *, P < 0.05; ***, P < 0.001 for comparison between baseline and follow-up in each group. KEGG, Kyoto Encyclopedia of Genes and Genomes.

Journal: Frontiers in Cellular and Infection Microbiology

Article Title: Longitudinal remodeling of gastric microbiota following Helicobacter pylori eradication reveals an eradication-associated microbial signature in gastric cancer

doi: 10.3389/fcimb.2026.1848437

Figure Lengend Snippet: Predicted functional pathways based on KEGG annotations associated with H. pylori infection and eradication status. (A) Relative representation of predicted pathways between H. pylori –negative and H. pylori –positive samples **, P < 0.01; ***, P < 0.001 for two-group comparison. (B) Relative changes in predicted functional pathways between baseline and follow-up samples across eradicated, recurrent GC after eradication, and non-eradicated groups. Functional profiles were predicted from 16S rRNA gene sequencing data using KEGG-based pathway inference. *, P < 0.05; ***, P < 0.001 for comparison between baseline and follow-up in each group. KEGG, Kyoto Encyclopedia of Genes and Genomes.

Article Snippet: The raw 16S rRNA gene sequencing data generated in this study have been deposited in the National Center for Biotechnology Information Sequence Read Archive under the BioProject accession number PRJNA1447187 and are publicly available at http://www.ncbi.nlm.nih.gov/bioproject/1447187 .

Techniques: Functional Assay, Infection, Comparison, Sequencing